InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfasc

Summary

InnateDB Protein

IDBP-192278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfasc

Protein Name

neurofascin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092148

InnateDB Gene

IDBG-192274 (Nfasc)

Protein Structure

UniProt Annotation

Function

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0086080	protein binding involved in heterotypic cell-cell adhesion

Biological Process

GO:0002175	protein localization to paranode region of axon
GO:0007411	axon guidance
GO:0007422	peripheral nervous system development
GO:0019226	transmission of nerve impulse
GO:0030913	paranodal junction assembly
GO:0034113	heterotypic cell-cell adhesion
GO:0045162	clustering of voltage-gated sodium channels
GO:0050808	synapse organization
GO:0071205	protein localization to juxtaparanode region of axon

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0033010	paranodal junction
GO:0033270	paranode region of axon
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:104753

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q810U3