InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nfasc

Summary

InnateDB Gene

IDBG-192274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfasc

Gene Name

neurofascin

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026442

Encoded Proteins

IDBP-192276

neurofascin

IDBP-192278

neurofascin

IDBP-627002

neurofascin

IDBP-789852

neurofascin

IDBP-789853

neurofascin

IDBP-789855

neurofascin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:132564690-132741797

Strand

Reverse strand

Band

Transcripts

ENSMUST00000043189	ENSMUSP00000035454
ENSMUST00000094569	ENSMUSP00000092148
ENSMUST00000163770	ENSMUSP00000132979
ENSMUST00000187861	ENSMUSP00000139955
ENSMUST00000186389	ENSMUSP00000140480
ENSMUST00000186330
ENSMUST00000188307	ENSMUSP00000139520
ENSMUST00000186539
ENSMUST00000191294
ENSMUST00000189219

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0086080	protein binding involved in heterotypic cell-cell adhesion

Biological Process

GO:0002175	protein localization to paranode region of axon
GO:0007411	axon guidance
GO:0007422	peripheral nervous system development
GO:0019226	transmission of nerve impulse
GO:0030913	paranodal junction assembly
GO:0034113	heterotypic cell-cell adhesion
GO:0045162	clustering of voltage-gated sodium channels
GO:0050808	synapse organization
GO:0071205	protein localization to juxtaparanode region of axon

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0033010	paranodal junction
GO:0033270	paranode region of axon
GO:0070062	extracellular vesicular exosome