InnateDB Protein
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IDBP-192313.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Synm
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Protein Name
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synemin, intermediate filament protein
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000050987
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InnateDB Gene
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IDBG-192311 (Synm)
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Protein Structure
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Function |
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:17356066}. Cell junction, adherens junction {ECO:0000250UniProtKB:O15061}. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere. {ECO:0000250UniProtKB:O15061, ECO:0000269PubMed:17356066}.
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Disease Associations |
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Tissue Specificity |
Isoform 2 and isoform 3 are detected in adult skeletal muscle, heart and bladder, whereas isoform 1 is only detected in adult bladder (at protein level). {ECO:0000269PubMed:15265691}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2661187
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InterPro |
IPR001664
Intermediate filament protein
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PFAM |
PF00038
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q70IV5
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PhosphoSite |
PhosphoSite-Q70IV5
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TrEMBL |
Q80XS8
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UniProt Splice Variant |
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Entrez Gene |
233335
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UniGene |
Mm.60526
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RefSeq |
NP_997546
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MGI ID |
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MGI Symbol |
Synm
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OMIM |
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CCDS |
CCDS39983
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HPRD |
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IMGT |
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EMBL |
AC158296
AJ579700
AJ579701
AJ579702
AK143019
AK172937
BC042785
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GenPept |
AAH42785
BAD32215
BAE25250
CAE30277
CAE30278
CAE30279
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