InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxn4

Summary

InnateDB Protein

IDBP-192326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxn4

Protein Name

forkhead box N4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047951

InnateDB Gene

IDBG-192324 (Foxn4)

Protein Structure

UniProt Annotation

Function

Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development. {ECO:0000269PubMed:15363391, ECO:0000269PubMed:16020526, ECO:0000269PubMed:17728344, ECO:0000269PubMed:21438071, ECO:0000269PubMed:22323600, ECO:0000269PubMed:23652001}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:22323600}.

Disease Associations

Tissue Specificity

Mainly expressed in proliferator progenitor cells in brain and retina rather than differentiated cells. In contrast, is expressed only in postmitotic epithelial cells rather than in proliferative progenitors in the proximal airway. {ECO:0000269PubMed:15363391, ECO:0000269PubMed:16020526, ECO:0000269PubMed:21438071}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001158	enhancer sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001947	heart looping
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0008016	regulation of heart contraction
GO:0009888	tissue development
GO:0010842	retina layer formation
GO:0030154	cell differentiation
GO:0035881	amacrine cell differentiation
GO:0036302	atrioventricular canal development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048513	organ development
GO:0048663	neuron fate commitment
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0060579	ventral spinal cord interneuron fate commitment