InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irak3

Summary

InnateDB Protein

IDBP-192501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irak3

Protein Name

interleukin-1 receptor-associated kinase 3

Synonyms

4833428C18Rik; AI563835; IRAK-M;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020448

InnateDB Gene

IDBG-192499 (Irak3)

Protein Structure

UniProt Annotation

Function

Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. {ECO:0000269PubMed:12054681, ECO:0000269PubMed:12150927, ECO:0000303PubMed:12150927}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in liver and thymus and at lower levels in heart, brain, spleen and kidney. {ECO:0000269PubMed:12054681}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0009615	response to virus
GO:0010933	positive regulation of macrophage tolerance induction
GO:0010936	negative regulation of macrophage cytokine production
GO:0019221	cytokine-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0032695	negative regulation of interleukin-12 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042177	negative regulation of protein catabolic process
GO:0042981	regulation of apoptotic process
GO:0043242	negative regulation of protein complex disassembly
GO:0043244	regulation of protein complex disassembly
GO:0043330	response to exogenous dsRNA
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045824	negative regulation of innate immune response
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070498	interleukin-1-mediated signaling pathway
GO:0070555	response to interleukin-1

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1921164

InterPro

IPR000488 Death domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011029 Death-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00531
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00005
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt