InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ugt8a

Summary

InnateDB Protein

IDBP-192504.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ugt8a

Protein Name

UDP galactosyltransferase 8A

Synonyms

AI850488; AW455908; Cgt; mCerGT; Ugt8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050852

InnateDB Gene

IDBG-192502 (Ugt8a)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
GO:0008120	ceramide glucosyltransferase activity
GO:0008489	UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0030246	carbohydrate binding

Biological Process

GO:0002175	protein localization to paranode region of axon
GO:0005975	carbohydrate metabolic process
GO:0006682	galactosylceramide biosynthetic process
GO:0007010	cytoskeleton organization
GO:0008088	axon cargo transport
GO:0008152	metabolic process
GO:0009247	glycolipid biosynthetic process
GO:0030259	lipid glycosylation
GO:0030913	paranodal junction assembly
GO:0042552	myelination
GO:0048812	neuron projection morphogenesis