Version 5.4
Mus musculus Gene: Ugt8a
Summary
InnateDB Gene IDBG-192502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ugt8a
Gene Name UDP galactosyltransferase 8A
Synonyms AI850488; AW455908; Cgt; mCerGT; Ugt8
Species Mus musculus
Ensembl Gene ENSMUSG00000032854
Encoded Proteins
IDBP-192504
UDP galactosyltransferase 8A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174607:
The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:125865359-125938550
Strand Reverse strand
Band G1
Transcripts
ENSMUST00000057944 ENSMUSP00000050852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003851 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
GO:0008120 ceramide glucosyltransferase activity
GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0030246 carbohydrate binding
Biological Process
GO:0002175 protein localization to paranode region of axon
GO:0005975 carbohydrate metabolic process
GO:0006682 galactosylceramide biosynthetic process
GO:0007010 cytoskeleton organization
GO:0008088 axon cargo transport
GO:0008152 metabolic process
GO:0009247 glycolipid biosynthetic process
GO:0030259 lipid glycosylation
GO:0030913 paranodal junction assembly
GO:0042552 myelination
GO:0048812 neuron projection morphogenesis
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174607
View Gene Order
ENSBTAG00000004574
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00600
Sphingolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q64676
TrEMBL
UniProt Splice Variant
Entrez Gene 22239
UniGene Mm.306021
RefSeq NM_011674 XM_006501309 XM_006501310
OMIM
CCDS CCDS17821
HPRD
IMGT
MGI ID MGI:109522
MGI Symbol Ugt8a
EMBL AK137364 BC016885 U48892 U48893 U48894 U48896 X92122 X92123 X92124 X92125 X92126 X92177
GenPept AAC53576 AAH16885 BAE23325 CAA63090 CAA63091
RNA Seq Atlas 22239

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca