InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr2f2

Summary

InnateDB Protein

IDBP-192530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr2f2

Protein Name

nuclear receptor subfamily 2, group F, member 2

Synonyms

2700033K02Rik; 9430015G03Rik; Aporp1; ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40; Tcfcoup2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032768

InnateDB Gene

IDBG-192528 (Nr2f2)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0001893	maternal placenta development
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001945	lymph vessel development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007519	skeletal muscle tissue development
GO:0009566	fertilization
GO:0009952	anterior/posterior pattern specification
GO:0009956	radial pattern formation
GO:0010596	negative regulation of endothelial cell migration
GO:0030522	intracellular receptor signaling pathway
GO:0030900	forebrain development
GO:0032355	response to estradiol
GO:0043401	steroid hormone mediated signaling pathway
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048514	blood vessel morphogenesis
GO:0060173	limb development
GO:0060674	placenta blood vessel development
GO:0060707	trophoblast giant cell differentiation
GO:0060849	regulation of transcription involved in lymphatic endothelial cell fate commitment

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1352452

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00545
PR00047
PR00398
PR01282

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt