InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msrb3

Summary

InnateDB Protein

IDBP-192682.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msrb3

Protein Name

methionine sulfoxide reductase B3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089781

InnateDB Gene

IDBG-192680 (Msrb3)

Protein Structure

UniProt Annotation

Function

Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000269PubMed:15249228}. Note=Not detected in the mitochondrion.

Disease Associations

Tissue Specificity

Widely expressed. Detected in the sensory epithelia of the organ of Corti and vestibular end organs as early as P2 up to adulthood (at protein level). In the organ of Corti, present in inner and outer hair cells and, to a lesser extent, in supporting cells (at protein level). In hair cells, distributed throughout the cell body. Barely detectable level in stereocilia. Also observed in spiral ganglion neurons, but not in the stria vascularis. In the vestibular end organs, found throughout the sensory epithelium, but more intense expression in hair cells than in supporting cells (at protein level). In vestibular hair cells, present within cell bodies and to a lesser extent in kinocilia. Barely detectable in stereocilia. {ECO:0000269PubMed:21185009}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0033743	peptide-methionine (R)-S-oxide reductase activity

Biological Process

GO:0006979	response to oxidative stress
GO:0030091	protein repair
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:2443538

InterPro

IPR002579 Peptide methionine sulphoxide reductase MrsB
IPR011057 Mss4-like

PFAM

PF01641

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BU85

PhosphoSite

PhosphoSite-Q8BU85

TrEMBL

UniProt Splice Variant

Entrez Gene

320183

UniGene

Mm.398652

RefSeq

NP_796066

MGI ID

MGI Symbol

Msrb3

OMIM

CCDS

CCDS24208

HPRD

IMGT

EMBL

AC138388 AK086975 AK137163 BC096447

GenPept

AAH96447 BAC39776 BAE23258