Version 5.4
Mus musculus Protein: Pum1
Summary
InnateDB Protein IDBP-192706.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pum1
Protein Name pumilio 1 (Drosophila)
Synonyms AA517475; mKIAA0099; Pumm;
Species Mus musculus
Ensembl Protein ENSMUSP00000095474
InnateDB Gene IDBG-192698 (Pum1)
Protein Structure
UniProt Annotation
Function Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. May be required to support proliferation and self-renewal of stem cells (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in brain, heart, kidney, liver, lung, skin, intestine, spleen, testis and thymus. Weakly or not expressed in muscles and stomach. Expressed at various stages of myeloid and lymphoid cell development. {ECO:0000269PubMed:12667987}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
Biological Process
GO:0006417 regulation of translation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1931749
InterPro IPR001313 Pumilio RNA-binding repeat
IPR016024 Armadillo-type fold
PFAM PF00806
PRINTS
PIRSF
SMART SM00025
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80U78
PhosphoSite PhosphoSite-Q80U78
TrEMBL Q3TQ21
UniProt Splice Variant
Entrez Gene 80912
UniGene Mm.470229
RefSeq NP_001153076
MGI ID
MGI Symbol Pum1
OMIM
CCDS CCDS51312
HPRD
IMGT
EMBL AF321909 AK052145 AK122205 AK163977 BC048174 BC050747
GenPept AAG42319 AAH48174 AAH50747 BAC34857 BAC65487 BAE37564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca