Version 5.4
Mus musculus Gene: Pum1
Summary
InnateDB Gene IDBG-192698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pum1
Gene Name pumilio 1 (Drosophila)
Synonyms AA517475; mKIAA0099; Pumm
Species Mus musculus
Ensembl Gene ENSMUSG00000028580
Encoded Proteins
IDBP-192700
pumilio 1 (Drosophila)
IDBP-192702
pumilio 1 (Drosophila)
IDBP-192706
pumilio 1 (Drosophila)
IDBP-269705
pumilio 1 (Drosophila)
IDBP-269707
pumilio 1 (Drosophila)
IDBP-541588
pumilio 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134644:
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3\' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:130663321-130781564
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000030315 ENSMUSP00000030315
ENSMUST00000097864 ENSMUSP00000095476
ENSMUST00000097862 ENSMUSP00000095474
ENSMUST00000105992 ENSMUSP00000101613
ENSMUST00000105991 ENSMUSP00000101612
ENSMUST00000122847
ENSMUST00000143277 ENSMUSP00000114629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006417 regulation of translation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134644
View Gene Order
ENSBTAG00000018979
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q80U78
TrEMBL Q3TQ21
UniProt Splice Variant
Entrez Gene 80912
UniGene Mm.407390 Mm.440206 Mm.470229
RefSeq NM_001159604 NM_001159603 NM_001159605 NM_001159606 NM_030722 XM_006537031 XM_006537032 XM_006537033 XM_006537034 XM_006537039 XM_006537040 XM_006537041 XM_006537047 XM_006537048 XM_006537049 XM_006537050 XM_006537051 XM_006537053 XM_006537054 XM_006539291 XM_006539292 XM_006539293 XM_006539294 XM_006539299 XM_006539300 XM_006539301 XM_006539307 XM_006539308 XM_006539309 XM_006539310 XM_006539311 XM_006539313 XM_006539314
OMIM
CCDS CCDS51312 CCDS18710 CCDS51311 CCDS51313 CCDS51314
HPRD
IMGT
MGI ID MGI:1931749
MGI Symbol Pum1
EMBL AF321909 AK052145 AK122205 AK163977 BC048174 BC050747
GenPept AAG42319 AAH48174 AAH50747 BAC34857 BAC65487 BAE37564
RNA Seq Atlas 80912

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca