Version 5.4
Mus musculus Protein: Nrtn
Summary
InnateDB Protein IDBP-192867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrtn
Protein Name neurturin
Synonyms NTN;
Species Mus musculus
Ensembl Protein ENSMUSP00000046512
InnateDB Gene IDBG-192865 (Nrtn)
Protein Structure
UniProt Annotation
Function Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Widespread distribution.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
Biological Process
GO:0001755 neural crest cell migration
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0021675 nerve development
GO:0031175 neuron projection development
Cellular Component
GO:0005576 extracellular region
GO:0030424 axon
Protein Structure and Domains
PDB ID MGI:108417
InterPro IPR001839 Transforming growth factor-beta, C-terminal
IPR029034 Cystine-knot cytokine
PFAM PF00019
PRINTS
PIRSF
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97463
PhosphoSite PhosphoSite-P97463
TrEMBL
UniProt Splice Variant
Entrez Gene 18188
UniGene Mm.8074
RefSeq NP_032764
MGI ID
MGI Symbol Nrtn
OMIM
CCDS CCDS28913
HPRD
IMGT
EMBL BC057993 U78109
GenPept AAC52954 AAH57993

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca