InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpru

Summary

InnateDB Protein

IDBP-193048.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpru

Protein Name

protein tyrosine phosphatase, receptor type, U

Synonyms

Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf; PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030741

InnateDB Gene

IDBG-193046 (Ptpru)

Protein Structure

UniProt Annotation

Function

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Transcripts of different sizes are differentially expressed in a subset of tissues. Detected in brain, lung, skeletal muscle, heart, kidney and placenta. In brain; expressed in olfactory bulb, cerebral cortex, hippocampus and cerebellum. {ECO:0000269PubMed:15040814, ECO:0000269PubMed:9054423, ECO:0000269PubMed:9272866}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0016311	dephosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0030154	cell differentiation
GO:0030336	negative regulation of cell migration
GO:0031100	organ regeneration
GO:0034109	homotypic cell-cell adhesion
GO:0034394	protein localization to cell surface
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0051384	response to glucocorticoid
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1321151

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000998 MAM domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00629
PF00041
PF01108

PRINTS

PR00700
PR00020

PIRSF

SMART

SM00194
SM00137
SM00404
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt