Version 5.4
Mus musculus Gene: Ptpru
Summary
InnateDB Gene IDBG-193046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptpru
Gene Name protein tyrosine phosphatase, receptor type, U
Synonyms Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf; PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda
Species Mus musculus
Ensembl Gene ENSMUSG00000028909
Encoded Proteins
IDBP-193048
protein tyrosine phosphatase, receptor type, U
IDBP-193050
protein tyrosine phosphatase, receptor type, U
IDBP-269714
protein tyrosine phosphatase, receptor type, U
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000060656:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:131768457-131838288
Strand Reverse strand
Band D2.3
Transcripts
ENSMUST00000030741 ENSMUSP00000030741
ENSMUST00000097860 ENSMUSP00000095472
ENSMUST00000105987 ENSMUSP00000101607
ENSMUST00000144136
ENSMUST00000127633
ENSMUST00000123878
ENSMUST00000154224
ENSMUST00000139641
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0016311 dephosphorylation
GO:0016337 single organismal cell-cell adhesion
GO:0030154 cell differentiation
GO:0030336 negative regulation of cell migration
GO:0031100 organ regeneration
GO:0034109 homotypic cell-cell adhesion
GO:0034394 protein localization to cell surface
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0051384 response to glucocorticoid
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000060656
View Gene Order
ENSBTAG00000012848
Not yet available
Pathways
NETPATH
REACTOME
REACT_188578
Signaling by SCF-KIT pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.404747 Mm.450810 Mm.4860
RefSeq NM_001083119 NM_011214 XM_006538666 XM_006538667 XM_006538668 XM_006538669 XM_006538670 XM_006538671 XM_006538672 XM_006538673 XM_006538674
OMIM
CCDS CCDS18714 CCDS38896
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca