InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dvl2

Summary

InnateDB Protein

IDBP-193131.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dvl2

Protein Name

dishevelled 2, dsh homolog (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019362

InnateDB Gene

IDBG-193127 (Dvl2)

Protein Structure

UniProt Annotation

Function

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. {ECO:0000269PubMed:17199046, ECO:0000269PubMed:20947020, ECO:0000269PubMed:21189423}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0043621	protein self-association

Biological Process

GO:0001843	neural tube closure
GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0007379	segment specification
GO:0007507	heart development
GO:0016055	Wnt signaling pathway
GO:0021535	cell migration in hindbrain
GO:0022007	convergent extension involved in neural plate elongation
GO:0034613	cellular protein localization
GO:0035282	segmentation
GO:0035556	intracellular signal transduction
GO:0035567	non-canonical Wnt signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046328	regulation of JNK cascade
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060029	convergent extension involved in organogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0030136	clathrin-coated vesicle
GO:0031410	cytoplasmic vesicle
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:106613

InterPro

IPR000591 DEP domain
IPR001158 DIX domain
IPR001478 PDZ domain
IPR003351 Dishevelled protein domain
IPR008339 Dishevelled family
IPR008341 Dishevelled-2
IPR024580 Dishevelled C-terminal

PFAM

PF00610
PF00778
PF00595
PF13180
PF02377
PF12316

PRINTS

PR01760
PR01762

PIRSF

SMART

SM00049
SM00021
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt