Version 5.4
Mus musculus Gene: Dvl2
Summary
InnateDB Gene IDBG-193127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dvl2
Gene Name dishevelled 2, dsh homolog (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020888
Encoded Proteins
IDBP-193129
dishevelled 2, dsh homolog (Drosophila)
IDBP-193131
dishevelled 2, dsh homolog (Drosophila)
IDBP-788619
dishevelled 2, dsh homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004975:
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40%% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70000595-70012301
Strand Forward strand
Band B3
Transcripts
ENSMUST00000102575 ENSMUSP00000099635
ENSMUST00000019362 ENSMUSP00000019362
ENSMUST00000130820
ENSMUST00000135422
ENSMUST00000149477
ENSMUST00000152732
ENSMUST00000190940 ENSMUSP00000140073
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 6 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 57 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043621 protein self-association
Biological Process
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0007379 segment specification
GO:0007507 heart development
GO:0016055 Wnt signaling pathway
GO:0021535 cell migration in hindbrain
GO:0022007 convergent extension involved in neural plate elongation
GO:0034613 cellular protein localization
GO:0035282 segmentation
GO:0035556 intracellular signal transduction
GO:0035567 non-canonical Wnt signaling pathway
GO:0043507 positive regulation of JUN kinase activity
GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046328 regulation of JNK cascade
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060029 convergent extension involved in organogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0030136 clathrin-coated vesicle
GO:0031410 cytoplasmic vesicle
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000004975
View Gene Order
ENSBTAG00000003075
Not yet available
Pathways
NETPATH
REACTOME
REACT_222404
WNT5A-dependent internalization of FZD4 pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_227429
degradation of DVL pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_256730
negative regulation of TCF-dependent signaling by DVL-interacting proteins pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_214043
PCP/CE pathway pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_196537
Signaling by Hippo pathway
REACT_203973
Asymmetric localization of PCP proteins pathway
REACT_188257
Signal Transduction pathway
REACT_225118
WNT mediated activation of DVL pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu04330
Notch signaling pathway pathway
mmu05217
Basal cell carcinoma pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_172581
PCP/CE pathway pathway
REACT_200668
WNT mediated activation of DVL pathway
REACT_228242
negative regulation of TCF-dependent signaling by DVL-interacting proteins pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_200841
degradation of DVL pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04330
Notch signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.5114
RefSeq NM_007888
OMIM
CCDS CCDS24930
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca