InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acer1

Summary

InnateDB Protein

IDBP-193172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acer1

Protein Name

alkaline ceramidase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062037

InnateDB Gene

IDBG-193170 (Acer1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids. {ECO:0000269PubMed:12783875}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12783875}; Multi-pass membrane protein {ECO:0000269PubMed:12783875}.

Disease Associations

Tissue Specificity

Highly expressed in skin. Weakly or not expressed in other tissues. {ECO:0000269PubMed:12783875}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017040	ceramidase activity
GO:0071633	dihydroceramidase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006672	ceramide metabolic process
GO:0008544	epidermis development
GO:0010446	response to alkalinity
GO:0019216	regulation of lipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0046512	sphingosine biosynthetic process
GO:0046514	ceramide catabolic process
GO:0071277	cellular response to calcium ion