InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acer1

Summary

InnateDB Gene

IDBG-193170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acer1

Gene Name

alkaline ceramidase 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045019

Encoded Proteins

IDBP-193172

alkaline ceramidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167769:
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:56953490-56982126

Strand

Reverse strand

Band

Transcripts

ENSMUST00000056113

ENSMUSP00000062037

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017040	ceramidase activity
GO:0071633	dihydroceramidase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006672	ceramide metabolic process
GO:0008544	epidermis development
GO:0010446	response to alkalinity
GO:0019216	regulation of lipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0046512	sphingosine biosynthetic process
GO:0046514	ceramide catabolic process
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000167769

View Gene Order

ENSBTAG00000008095

Not yet available

Pathways

NETPATH

REACTOME

REACT_198151

Sphingolipid de novo biosynthesis pathway

REACT_188937

Metabolism pathway

REACT_245163

Sphingolipid metabolism pathway

REACT_232291

Metabolism of lipids and lipoproteins pathway

KEGG

mmu00600

Sphingolipid metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_115810

Sphingolipid de novo biosynthesis pathway

REACT_19323

Sphingolipid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00600

Sphingolipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

Q8R4X1

TrEMBL

UniProt Splice Variant

Entrez Gene

171168

UniGene

Mm.218784

RefSeq

NM_175731

OMIM

CCDS

CCDS28919

HPRD

IMGT

MGI ID

MGI:2181962

MGI Symbol

Acer1

EMBL

AF347023 AK028901 AK075884 BC130254

GenPept

AAI30255 AAL83821 BAC26186 BAC36029

RNA Seq Atlas

171168