InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clpp

Summary

InnateDB Protein

IDBP-193205.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clpp

Protein Name

caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)

Synonyms

AU019820; D17Wsu160e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002735

InnateDB Gene

IDBG-193203 (Clpp)

Protein Structure

UniProt Annotation

Function

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:10754102, ECO:0000269PubMed:22710082}.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). High levels found in heart, liver and skeletal muscle. {ECO:0000269PubMed:10754102, ECO:0000269PubMed:22710082}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0051260	protein homooligomerization
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0009368	endopeptidase Clp complex

Protein Structure and Domains

PDB ID

MGI:1858213

InterPro

IPR001907 ATP-dependent Clp protease proteolytic subunit
IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA
IPR029045 ClpP/crotonase-like domain

PFAM

PF00574

PRINTS

PR00127

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88696