InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sppl3

Summary

InnateDB Protein

IDBP-193232.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sppl3

Protein Name

signal peptide peptidase 3

Synonyms

4833416I09Rik; Psl4; Usmg3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031530

InnateDB Gene

IDBG-193230 (Sppl3)

Protein Structure

UniProt Annotation

Function

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Restricted to the early secretory compartment. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving
GO:0042803	protein homodimerization activity

Biological Process

GO:0045087

innate immune response (InnateDB)

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane