InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chi3l1

Summary

InnateDB Protein

IDBP-193404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chi3l1

Protein Name

chitinase 3-like 1

Synonyms

AW208766; Brp39; Chi3l1; Gp39;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080717

InnateDB Gene

IDBG-193402 (Chi3l1)

Protein Structure

UniProt Annotation

Function

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269PubMed:16472595, ECO:0000269PubMed:19041398, ECO:0000269PubMed:19414556, ECO:0000269PubMed:20558631, ECO:0000269PubMed:21546314, ECO:0000269PubMed:22817986}.

Subcellular Localization

Secreted, extracellular space. Cytoplasm. Endoplasmic reticulum. Note=Detected in bronchoalveolar lavage (BAL) fluids. Localizes mainly to endoplasmic reticulum when overexpressed in cells, with some protein also detected throughout the cytoplasm.

Disease Associations

Tissue Specificity

Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon. {ECO:0000269PubMed:16472595, ECO:0000269PubMed:19414556, ECO:0000269PubMed:20558631, ECO:0000269PubMed:21866546}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity
GO:0008061	chitin binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006032	chitin catabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0009612	response to mechanical stimulus
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0030324	lung development
GO:0034612	response to tumor necrosis factor
GO:0045766	positive regulation of angiogenesis
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070555	response to interleukin-1
GO:0070741	response to interleukin-6
GO:0071356	cellular response to tumor necrosis factor
GO:0072606	interleukin-8 secretion

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1340899

InterPro

IPR001223 Glycoside hydrolase, family 18, catalytic domain
IPR011583 Chitinase II
IPR017853 Glycoside hydrolase, superfamily
IPR029070 Chitinase insertion domain

PFAM

PF00704

PRINTS

PIRSF

SMART

SM00636

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61362