InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chi3l1

Summary

InnateDB Gene

IDBG-193402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chi3l1

Gene Name

chitinase 3-like 1

Synonyms

AW208766; Brp39; Chi3l1; Gp39

Species

Mus musculus

Ensembl Gene

ENSMUSG00000064246

Encoded Proteins

IDBP-193404

chitinase 3-like 1

IDBP-533649

chitinase 3-like 1

IDBP-533999

chitinase 3-like 1

IDBP-540798

chitinase 3-like 1

IDBP-540782

chitinase 3-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133048:
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:134182176-134190181

Strand

Forward strand

Band

Transcripts

ENSMUST00000082060	ENSMUSP00000080717
ENSMUST00000156873	ENSMUSP00000119205
ENSMUST00000153856	ENSMUSP00000117117
ENSMUST00000133701	ENSMUSP00000121471
ENSMUST00000132873	ENSMUSP00000118289
ENSMUST00000139254
ENSMUST00000144819
ENSMUST00000134812

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity
GO:0008061	chitin binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006032	chitin catabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0009612	response to mechanical stimulus
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0030324	lung development
GO:0034612	response to tumor necrosis factor
GO:0045766	positive regulation of angiogenesis
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070555	response to interleukin-1
GO:0070741	response to interleukin-6
GO:0071356	cellular response to tumor necrosis factor
GO:0072606	interleukin-8 secretion

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000133048

View Gene Order

ENSBTAG00000018223

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.38274 Mm.407568

RefSeq

NM_007695 XM_006529111 XM_006529112

OMIM

CCDS

CCDS48368

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas