InnateDB Protein
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IDBP-193464.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc1a2
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Protein Name
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solute carrier family 1 (glial high affinity glutamate transporter), member 2
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Synonyms
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1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; GLT-1; GLT1; MGLT1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000079100
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InnateDB Gene
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IDBG-193462 (Slc1a2)
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Protein Structure
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Function |
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Isoform GLT1 is expressed in the brain. Isoforms GLT-1A and GLT-1B are expressed in the liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
|
Protein-Protein |
10
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005313
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L-glutamate transmembrane transporter activity
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GO:0005515
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protein binding
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GO:0015501
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glutamate:sodium symporter activity
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GO:0017153
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sodium:dicarboxylate symporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:101931
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InterPro |
IPR001991
Sodium:dicarboxylate symporter
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PFAM |
PF00375
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PRINTS |
PR00173
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P43006
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PhosphoSite |
PhosphoSite-P43006
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TrEMBL |
Q3UYK6
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UniProt Splice Variant |
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Entrez Gene |
20511
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UniGene |
Mm.479346
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RefSeq |
NP_001070982
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MGI ID |
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MGI Symbol |
Slc1a2
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OMIM |
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CCDS |
CCDS38188
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HPRD |
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IMGT |
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EMBL |
AB007810
AB007811
AB007812
AK134609
AL844155
AL844605
CH466519
D43796
U11763
U24699
U75372
U75373
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GenPept |
AAA77673
AAA91643
AAB71737
AAB71738
BAA07854
BAA23770
BAA23771
BAA23772
BAE22206
CAM27623
CAM27626
EDL27674
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