InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc1a2

Summary

InnateDB Gene

IDBG-193462.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc1a2

Gene Name

solute carrier family 1 (glial high affinity glutamate transporter), member 2

Synonyms

1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; GLT-1; GLT1; MGLT1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005089

Encoded Proteins

IDBP-193464

solute carrier family 1 (glial high affinity glutamate transporter), member 2

IDBP-193466

solute carrier family 1 (glial high affinity glutamate transporter), member 2

IDBP-258602

solute carrier family 1 (glial high affinity glutamate transporter), member 2

IDBP-258604

solute carrier family 1 (glial high affinity glutamate transporter), member 2

IDBP-539357

solute carrier family 1 (glial high affinity glutamate transporter), member 2

IDBP-542611

solute carrier family 1 (glial high affinity glutamate transporter), member 2

IDBP-540494

solute carrier family 1 (glial high affinity glutamate transporter), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110436:
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:102658659-102790784

Strand

Forward strand

Band

Transcripts

ENSMUST00000080210	ENSMUSP00000079100
ENSMUST00000005220	ENSMUSP00000005220
ENSMUST00000111213	ENSMUSP00000106844
ENSMUST00000111212	ENSMUSP00000106843
ENSMUST00000125085
ENSMUST00000145921
ENSMUST00000136221
ENSMUST00000137466
ENSMUST00000123759	ENSMUSP00000115129
ENSMUST00000128622
ENSMUST00000136488	ENSMUSP00000122094
ENSMUST00000154446	ENSMUSP00000117549

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005515	protein binding
GO:0015501	glutamate:sodium symporter activity
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006835	dicarboxylic acid transport
GO:0007399	nervous system development
GO:0007632	visual behavior
GO:0009416	response to light stimulus
GO:0009611	response to wounding
GO:0010259	multicellular organismal aging
GO:0015813	L-glutamate transport
GO:0021537	telencephalon development
GO:0030534	adult behavior
GO:0031668	cellular response to extracellular stimulus
GO:0035264	multicellular organism growth
GO:0042493	response to drug
GO:0043200	response to amino acid
GO:0046326	positive regulation of glucose import
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0070779	D-aspartate import