InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMGCS1

Summary

InnateDB Protein

IDBP-19363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCS1

Protein Name

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Synonyms

HMGCS;

Species

Homo sapiens

Ensembl Protein

ENSP00000322706

InnateDB Gene

IDBG-19361 (HMGCS1)

Protein Structure

UniProt Annotation

Function

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004421	hydroxymethylglutaryl-CoA synthase activity
GO:0008144	drug binding
GO:0016853	isomerase activity
GO:0042803	protein homodimerization activity
GO:0043177	organic acid binding

Biological Process

GO:0001889	liver development
GO:0006629	lipid metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0007420	brain development
GO:0008152	metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0008584	male gonad development
GO:0009645	response to low light intensity stimulus
GO:0009725	response to hormone
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0014074	response to purine-containing compound
GO:0033197	response to vitamin E
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046690	response to tellurium ion
GO:0055094	response to lipoprotein particle stimulus
GO:0070723	response to cholesterol
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0071397	cellular response to cholesterol
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
IPR016039 Thiolase-like

PFAM

PF01154
PF08540

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q01581

PhosphoSite