InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mfge8

Summary

InnateDB Protein

IDBP-193648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mfge8

Protein Name

milk fat globule-EGF factor 8 protein

Synonyms

AA408458; AI325141; lactadherin; MFG-E8; Mfgm; MP47; P47; SED1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032825

InnateDB Gene

IDBG-193646 (Mfge8)

Protein Structure

UniProt Annotation

Function

Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha- v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. {ECO:0000250, ECO:0000269PubMed:15834428, ECO:0000269PubMed:18008006}.

Subcellular Localization

Membrane {ECO:0000269PubMed:2122462}; Peripheral membrane protein {ECO:0000269PubMed:2122462}. Secreted {ECO:0000269PubMed:2122462}.

Disease Associations

Tissue Specificity

Mammary epithelial cell surfaces and spermatozoan. Isoform 2 is present in brain, heart, kidney and spleen and at low levels in lung, liver, small intestine and testis. {ECO:0000269PubMed:2122462, ECO:0000269PubMed:9920772}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008429	phosphatidylethanolamine binding

Biological Process

GO:0001525	angiogenesis
GO:0006910	phagocytosis, recognition
GO:0006911	phagocytosis, engulfment
GO:0007155	cell adhesion
GO:0007338	single fertilization
GO:0045087	innate immune response (InnateDB)
GO:0050766	positive regulation of phagocytosis
GO:2000427	positive regulation of apoptotic cell clearance

Cellular Component

GO:0005615	extracellular space
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0019897	extrinsic component of plasma membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome