InnateDB Protein
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IDBP-19369.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KIF23
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Protein Name
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kinesin family member 23
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Synonyms
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CHO1; KNSL5; MKLP-1; MKLP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000304978
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InnateDB Gene
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IDBG-19367 (KIF23)
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Protein Structure
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Function |
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269PubMed:16103226, ECO:0000269PubMed:16236794, ECO:0000269PubMed:22522702}.
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Subcellular Localization |
Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
46
[view]
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Protein-Protein |
45
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001752
Kinesin, motor domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00225
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PRINTS |
PR00380
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PIRSF |
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SMART |
SM00129
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TIGRFAMs |
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Modification |
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SwissProt |
Q02241
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PhosphoSite |
PhosphoSite-Q02241
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9493
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UniGene |
Hs.270845
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RefSeq |
XP_005254856
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HUGO |
HGNC:6392
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OMIM |
605064
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CCDS |
CCDS32279
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HPRD |
05455
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IMGT |
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EMBL |
BC017705
BC051826
X67155
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GenPept |
AAH17705
AAH51826
CAA47628
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