InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIF23

Summary

InnateDB Gene

IDBG-19367.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF23

Gene Name

kinesin family member 23

Synonyms

CHO1; KNSL5; MKLP-1; MKLP1

Species

Homo sapiens

Ensembl Gene

ENSG00000137807

Encoded Proteins

IDBP-19369

kinesin family member 23

IDBP-19371

kinesin family member 23

IDBP-239633

kinesin family member 23

IDBP-587377

kinesin family member 23

IDBP-600354

kinesin family member 23

IDBP-593157

kinesin family member 23

IDBP-591172

kinesin family member 23

IDBP-597454

kinesin family member 23

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:69414246-69448427

Strand

Forward strand

Band

q23

Transcripts

ENST00000352331	ENSP00000304978
ENST00000260363	ENSP00000260363
ENST00000395392	ENSP00000378790
ENST00000559279	ENSP00000453386
ENST00000561089	ENSP00000453629
ENST00000558346	ENSP00000453576
ENST00000560042
ENST00000558585	ENSP00000453102
ENST00000559283	ENSP00000452901
ENST00000559456
ENST00000558303
ENST00000560125
ENST00000559944

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0000022	mitotic spindle elongation
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0007018	microtubule-based movement
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032467	positive regulation of cytokinesis
GO:0051256	spindle midzone assembly involved in mitosis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0030496	midbody
GO:0045171	intercellular bridge
GO:0072686	mitotic spindle
GO:0097149	centralspindlin complex