InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF23

Summary

InnateDB Protein

IDBP-19371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF23

Protein Name

kinesin family member 23

Synonyms

CHO1; KNSL5; MKLP-1; MKLP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000260363

InnateDB Gene

IDBG-19367 (KIF23)

Protein Structure

UniProt Annotation

Function

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269PubMed:16103226, ECO:0000269PubMed:16236794, ECO:0000269PubMed:22522702}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0000022	mitotic spindle elongation
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0007018	microtubule-based movement
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032467	positive regulation of cytokinesis
GO:0051256	spindle midzone assembly involved in mitosis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0030496	midbody
GO:0045171	intercellular bridge
GO:0072686	mitotic spindle
GO:0097149	centralspindlin complex