Version 5.4
Mus musculus Protein: Pla2g12a
Summary
InnateDB Protein IDBP-193767.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g12a
Protein Name phospholipase A2, group XIIA
Synonyms 2310004B05Rik; GXII; GXII-1; GXII-1-PLA2; mGXII-1; Pla2g12; Rossy;
Species Mus musculus
Ensembl Protein ENSMUSP00000053651
InnateDB Gene IDBG-193763 (Pla2g12a)
Protein Structure
UniProt Annotation
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine (By similarity). {ECO:0000250}.
Subcellular Localization Secreted. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:1913600
InterPro IPR010711 Phospholipase A2, group XII secretory
IPR016090 Phospholipase A2 domain
PFAM PF06951
PF00068
PRINTS
PIRSF
SMART SM00085
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EPR2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66350
UniGene Mm.468799
RefSeq NP_904359
MGI ID
MGI Symbol Pla2g12a
OMIM
CCDS CCDS17837
HPRD
IMGT
EMBL AK003183 AK009133 AK010011 AK010174 AK163693 AY007381 AY007382 BC051117
GenPept AAG23336 AAG23337 AAH51117 BAB26094 BAB26641 BAB26747 BAE37460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca