InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ehf

Summary

InnateDB Protein

IDBP-193809.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ehf

Protein Name

ets homologous factor

Synonyms

9030625L19Rik; AU019492;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087961

InnateDB Gene

IDBG-193807 (Ehf)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter (By similarity). {ECO:0000250UniProtKB:Q9NZC4, ECO:0000269PubMed:16704374}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:Q9NZC4, ECO:0000255PROSITE-ProRule:PRU00237}.

Disease Associations

Tissue Specificity

Highly expressed in kidney and lung, weakly in skeletal muscle, heart, and liver, and not detected in brain, spleen or testis. {ECO:0000269PubMed:9600089}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0030855	epithelial cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter