InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Avil

Summary

InnateDB Protein

IDBP-193826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Avil

Protein Name

advillin

Synonyms

Advil; DOC6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026500

InnateDB Gene

IDBG-193824 (Avil)

Protein Structure

UniProt Annotation

Function

Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. {ECO:0000269PubMed:15247299, ECO:0000269PubMed:18160648}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection {ECO:0000250}. Cell projection, axon {ECO:0000250}.

Disease Associations

Tissue Specificity

Most highly expressed in the endometrium of the uterus, the intestinal villi and the testes. Weaker expression also detected in the brain, dorsal root ganglions and on the surface of the tongue. {ECO:0000269PubMed:15247299, ECO:0000269PubMed:18160648, ECO:0000269PubMed:9664034}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0010976	positive regulation of neuron projection development
GO:0051693	actin filament capping
GO:0060271	cilium morphogenesis