InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kars

Summary

InnateDB Protein

IDBP-193867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kars

Protein Name

lysyl-tRNA synthetase

Synonyms

AA589550; AL024334; AL033315; AL033367; D8Ertd698e; D8Wsu108e; LysRS; mKIAA0070;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034426

InnateDB Gene

IDBG-193865 (Kars)

Protein Structure

UniProt Annotation

Function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004824	lysine-tRNA ligase activity
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006430	lysyl-tRNA aminoacylation

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1934754

InterPro

IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
IPR002313 Lysine-tRNA ligase, class II
IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR012340 Nucleic acid-binding, OB-fold
IPR018149 Lysyl-tRNA synthetase, class II, C-terminal

PFAM

PF00152
PF01336

PRINTS

PR01042
PR00982

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99MN1