InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pxn

Summary

InnateDB Protein

IDBP-193900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pxn

Protein Name

paxillin

Synonyms

AW108311; AW123232; Pax;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069624

InnateDB Gene

IDBG-193898 (Pxn)

Protein Structure

UniProt Annotation

Function

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269PubMed:8940124}. Note=Colocalizes with integrins at the cell periphery.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 172 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	172 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030159	receptor signaling complex scaffold activity
GO:0051435	BH4 domain binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006928	cellular component movement
GO:0007010	cytoskeleton organization
GO:0007229	integrin-mediated signaling pathway
GO:0008360	regulation of cell shape
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030032	lamellipodium assembly
GO:0034446	substrate adhesion-dependent cell spreading
GO:0045860	positive regulation of protein kinase activity
GO:0048041	focal adhesion assembly
GO:0048754	branching morphogenesis of an epithelial tube

Cellular Component

GO:0005856	cytoskeleton
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0030027	lamellipodium
GO:0031252	cell leading edge

Protein Structure and Domains

PDB ID

MGI:108295

InterPro

IPR001781 Zinc finger, LIM-type
IPR001904 Paxillin

PFAM

PF00412

PRINTS

PR00832

PIRSF

SMART

SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VI36

PhosphoSite

PhosphoSite-Q8VI36

TrEMBL

UniProt Splice Variant

Entrez Gene

19303

UniGene

RefSeq

NP_035353

MGI ID

MGI Symbol

Pxn

OMIM

CCDS

CCDS19593

HPRD

IMGT

EMBL

AF293882 AF293883 AK149933 AK157688 AK167299 AK171436

GenPept

AAL71909 AAL71910 BAE29176 BAE34151 BAE39404 BAE42452