InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pxn

Summary

InnateDB Protein

IDBP-193902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pxn

Protein Name

paxillin

Synonyms

AW108311; AW123232; Pax;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083709

InnateDB Gene

IDBG-193898 (Pxn)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 172 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	172 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008270	zinc ion binding
GO:0017166	vinculin binding
GO:0019901	protein kinase binding
GO:0030159	receptor signaling complex scaffold activity
GO:0032403	protein complex binding
GO:0051435	BH4 domain binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006928	cellular component movement
GO:0007010	cytoskeleton organization
GO:0007229	integrin-mediated signaling pathway
GO:0008360	regulation of cell shape
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030032	lamellipodium assembly
GO:0034446	substrate adhesion-dependent cell spreading
GO:0034614	cellular response to reactive oxygen species
GO:0045860	positive regulation of protein kinase activity
GO:0048041	focal adhesion assembly
GO:0048754	branching morphogenesis of an epithelial tube
GO:0060396	growth hormone receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0030027	lamellipodium
GO:0031252	cell leading edge