InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kdm5b

Summary

InnateDB Protein

IDBP-193933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm5b

Protein Name

lysine (K)-specific demethylase 5B

Synonyms

2010009J12Rik; 2210016I17Rik; AW556288; D1Ertd202e; Jarid1b; mKIAA4034; PLU-1; Plu1; PUT1; Rb-Bp2; RBBP2H1A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038138

InnateDB Gene

IDBG-193931 (Kdm5b)

Protein Structure

UniProt Annotation

Function

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. {ECO:0000269PubMed:17310255, ECO:0000269PubMed:17320160}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000255PROSITE-ProRule:PRU00537, ECO:0000269PubMed:14579128}.

Disease Associations

Tissue Specificity

Present at highest levels in testis, where it is enriched in spermatogonia and pachytene cells (at protein level). {ECO:0000269PubMed:12237901, ECO:0000269PubMed:14516692, ECO:0000269PubMed:14579128}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453	histone demethylase activity (H3-K4 specific)
GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)
GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0034720	histone H3-K4 demethylation
GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

MGI:1922855

InterPro

IPR001606 ARID/BRIGHT DNA-binding domain
IPR001965 Zinc finger, PHD-type
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR004198 Zinc finger, C5HC2-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR013637 Lysine-specific demethylase-like domain
IPR019787 Zinc finger, PHD-finger

PFAM