InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phactr4

Summary

InnateDB Protein

IDBP-193957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phactr4

Protein Name

phosphatase and actin regulator 4

Synonyms

3110001B12Rik; AI527228; AW495572; C330013F19Rik; mKIAA4120; N28169;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081270

InnateDB Gene

IDBG-193951 (Phactr4)

Protein Structure

UniProt Annotation

Function

Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway. {ECO:0000269PubMed:17609112, ECO:0000269PubMed:22215812}.

Subcellular Localization

Cytoplasm. Cell projection, lamellipodium.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004864	protein phosphatase inhibitor activity
GO:0008157	protein phosphatase 1 binding
GO:0071862	protein phosphatase type 1 activator activity

Biological Process

GO:0001755	neural crest cell migration
GO:0001843	neural tube closure
GO:0007266	Rho protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0043085	positive regulation of catalytic activity
GO:0043086	negative regulation of catalytic activity
GO:0048484	enteric nervous system development
GO:0051726	regulation of cell cycle
GO:0061386	closure of optic fissure
GO:2001045	negative regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

MGI:2140327

InterPro

IPR004018 RPEL repeat

PFAM

PF02755

PRINTS

PIRSF

SMART

SM00707

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q501J7

PhosphoSite

PhosphoSite-Q501J7

TrEMBL

UniProt Splice Variant

Entrez Gene

100169

UniGene

Mm.158361

RefSeq

MGI ID

MGI Symbol

Phactr4

OMIM

CCDS

HPRD

IMGT

EMBL

AK049209 AK220496 AL805897 BC075672 BC096033

GenPept

AAH75672 AAH96033 BAC33611 BAD90294 CAM26520 CAM26521 CAM26523