InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polg

Summary

InnateDB Protein

IDBP-193976.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Polg

Protein Name

polymerase (DNA directed), gamma

Synonyms

AA409516; PolgA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073551

InnateDB Gene

IDBG-193972 (Polg)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0004527	exonuclease activity
GO:0005515	protein binding

Biological Process

GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0006264	mitochondrial DNA replication
GO:0006287	base-excision repair, gap-filling
GO:0007568	aging
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005760	gamma DNA polymerase complex
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1196389

InterPro

IPR001098 DNA-directed DNA polymerase, family A, palm domain
IPR002297 DNA-directed DNA-polymerase, family A, mitochondria
IPR012337 Ribonuclease H-like domain
IPR016265 DNA-directed DNA polymerase, family A, mitochondria, subgroup

PFAM

PF00476

PRINTS

PR00867

PIRSF

PIRSF000797

SMART

SM00482

TIGRFAMs

Post-translational Modifications

Modification

Cross-References