InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Polg

Summary

InnateDB Gene

IDBG-193972.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polg

Gene Name

polymerase (DNA directed), gamma

Synonyms

AA409516; PolgA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039176

Encoded Proteins

IDBP-193976

polymerase (DNA directed), gamma

IDBP-534003

polymerase (DNA directed), gamma

IDBP-537496

polymerase (DNA directed), gamma

IDBP-533415

polymerase (DNA directed), gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140521:
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:79448791-79466362

Strand

Reverse strand

Band

Transcripts

ENSMUST00000073889	ENSMUSP00000073551
ENSMUST00000127082
ENSMUST00000154403
ENSMUST00000139290
ENSMUST00000149444	ENSMUSP00000119616
ENSMUST00000145154
ENSMUST00000139795
ENSMUST00000139597
ENSMUST00000132048
ENSMUST00000127734
ENSMUST00000139668	ENSMUSP00000114414
ENSMUST00000143672	ENSMUSP00000122286
ENSMUST00000142915
ENSMUST00000125562

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0004527	exonuclease activity
GO:0005515	protein binding

Biological Process

GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0006264	mitochondrial DNA replication
GO:0006287	base-excision repair, gap-filling
GO:0007568	aging
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005760	gamma DNA polymerase complex
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000140521

View Gene Order

ENSBTAG00000009098

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.3616 Mm.487623

RefSeq

NM_017462 XM_006540709 XM_006540710 XM_006540711

OMIM

CCDS

CCDS21382

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas