InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alox12

Summary

InnateDB Protein

IDBP-194007.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alox12

Protein Name

arachidonate 12-lipoxygenase

Synonyms

9930022G08Rik; Alox12p; P-12LO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000329

InnateDB Gene

IDBG-194005 (Alox12)

Protein Structure

UniProt Annotation

Function

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269PubMed:9501222}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:7868854}. Membrane {ECO:0000250}. Note=Membrane association is stimulated by EGF. {ECO:0000250}.

Disease Associations

Tissue Specificity

Found primarily in platelets and in microsomal and cytosolic fractions of the epidermis (at protein level). {ECO:0000269PubMed:10383730, ECO:0000269PubMed:8188678, ECO:0000269PubMed:9501222}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004052	arachidonate 12-lipoxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016165	lipoxygenase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding
GO:0047977	hepoxilin-epoxide hydrolase activity

Biological Process

GO:0006928	cellular component movement
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0010595	positive regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0010942	positive regulation of cell death
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0019395	fatty acid oxidation
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043651	linoleic acid metabolic process
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0045909	positive regulation of vasodilation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051122	hepoxilin biosynthetic process
GO:0051901	positive regulation of mitochondrial depolarization
GO:0055114	oxidation-reduction process
GO:0061436	establishment of skin barrier
GO:0071396	cellular response to lipid
GO:0090331	negative regulation of platelet aggregation
GO:1901751	leukotriene A4 metabolic process
GO:2001303	lipoxin A4 biosynthetic process
GO:2001306	lipoxin B4 biosynthetic process