InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Alox12

Summary

InnateDB Gene

IDBG-194005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alox12

Gene Name

arachidonate 12-lipoxygenase

Synonyms

9930022G08Rik; Alox12p; P-12LO

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000320

Encoded Proteins

IDBP-194007

arachidonate 12-lipoxygenase

IDBP-264244

arachidonate 12-lipoxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108839:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:70241457-70255353

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000329	ENSMUSP00000000329
ENSMUST00000108574	ENSMUSP00000104214

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004052	arachidonate 12-lipoxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016165	lipoxygenase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding
GO:0047977	hepoxilin-epoxide hydrolase activity

Biological Process

GO:0006928	cellular component movement
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0010595	positive regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0010942	positive regulation of cell death
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0019395	fatty acid oxidation
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043651	linoleic acid metabolic process
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0045909	positive regulation of vasodilation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051122	hepoxilin biosynthetic process
GO:0051901	positive regulation of mitochondrial depolarization
GO:0055114	oxidation-reduction process
GO:0061436	establishment of skin barrier
GO:0071396	cellular response to lipid
GO:0090331	negative regulation of platelet aggregation
GO:1901751	leukotriene A4 metabolic process
GO:2001303	lipoxin A4 biosynthetic process
GO:2001306	lipoxin B4 biosynthetic process