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InnateDB Protein
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IDBP-194010.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Med18
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Protein Name
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mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
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Synonyms
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2810046C01Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099627
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InnateDB Gene
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IDBG-194008 (Med18)
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Protein Structure
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| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus {ECO:0000305}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
3
[view]
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| Protein-Protein |
3
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
43 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0005515
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protein binding
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| Biological Process |
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0008150
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biological_process
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| Cellular Component |
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| PDB ID |
MGI:1914469
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| InterPro |
IPR019095
Mediator complex, subunit Med18, metazoa/fungi
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| PFAM |
PF09637
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q9CZ82
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| PhosphoSite |
PhosphoSite-Q9CZ82
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
67219
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| UniGene |
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| RefSeq |
NP_080315
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| MGI ID |
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| MGI Symbol |
Med18
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| OMIM |
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| CCDS |
CCDS18725
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| HPRD |
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| IMGT |
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| EMBL |
AK012886
AK159696
AL805897
BC068306
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| GenPept |
AAH68306
BAB28536
BAE35296
CAM26519
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Version 5.4