Version 5.4
Mus musculus Protein: Col25a1
Summary
InnateDB Protein IDBP-194092.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col25a1
Protein Name collagen, type XXV, alpha 1
Synonyms 2700062B08Rik; CLAC-P;
Species Mus musculus
Ensembl Protein ENSMUSP00000079210
InnateDB Gene IDBG-194088 (Col25a1)
Protein Structure
UniProt Annotation
Function Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity). {ECO:0000250UniProtKB:Q9BXS0}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed predominantly in neurons with low levels also detected in heart, testis and eye. {ECO:0000269PubMed:11927537}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0008201 heparin binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:1924268
InterPro IPR008160 Collagen triple helix repeat
PFAM PF01391
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99MQ5
PhosphoSite PhosphoSite-Q99MQ5
TrEMBL B2RQR7
UniProt Splice Variant
Entrez Gene 77018
UniGene Mm.422166
RefSeq NP_084114
MGI ID
MGI Symbol Col25a1
OMIM
CCDS CCDS38637
HPRD
IMGT
EMBL AC091312 AC110540 AC114642 AC164078 AF315290 BC138051 CH466532
GenPept AAI38052 AAK37475 EDL12220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca