Version 5.4
| Mus musculus Gene: Col25a1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-194088.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Col25a1 | ||||||||
| Gene Name | collagen, type XXV, alpha 1 | ||||||||
| Synonyms | 2700062B08Rik; CLAC-P | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000058897 | ||||||||
| Encoded Proteins |
collagen, type XXV, alpha 1
collagen, type XXV, alpha 1
collagen, type XXV, alpha 1
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188517:
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 3:130180891-130599877 | ||||||||
| Strand | Forward strand | ||||||||
| Band | G3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Collagen formation pathway
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Collagen degradation pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Collagen biosynthesis and modifying enzymes pathway
Collagen degradation pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Collagen formation pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | V9GWX5 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 77018 | ||||||||
| UniGene | |||||||||
| RefSeq | NM_001244952 NM_029838 NM_198711 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS38636 CCDS38637 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1924268 | ||||||||
| MGI Symbol | Col25a1 | ||||||||
| EMBL | AC091312 AC110540 AC114642 AC164078 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 77018 | ||||||||