InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ticrr

Summary

InnateDB Protein

IDBP-194116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ticrr

Protein Name

RIKEN cDNA 5730590G19 gene

Synonyms

5730590G19Rik; BC028450; Lrrk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041377

InnateDB Gene

IDBG-194114 (Ticrr)

Protein Structure

UniProt Annotation

Function

Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Associates with chromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0001731	formation of translation preinitiation complex
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0010212	response to ionizing radiation
GO:0030174	regulation of DNA-dependent DNA replication initiation
GO:0033314	mitotic DNA replication checkpoint