InnateDB Protein
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IDBP-194189.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Os9
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Protein Name
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amplified in osteosarcoma
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000079770
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InnateDB Gene
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IDBG-194187 (Os9)
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Protein Structure
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Function |
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum lumen {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
43 [view]
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Molecular Function |
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Biological Process |
GO:0006605
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protein targeting
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GO:0006621
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protein retention in ER lumen
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GO:0016567
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protein ubiquitination
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GO:0030433
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ER-associated ubiquitin-dependent protein catabolic process
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GO:0034976
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response to endoplasmic reticulum stress
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GO:0042787
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protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Cellular Component |
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PDB ID |
MGI:1924301
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InterPro |
IPR009011
Mannose-6-phosphate receptor binding domain
IPR012913
Glucosidase II beta subunit-like
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PFAM |
PF07915
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K2C7
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PhosphoSite |
PhosphoSite-Q8K2C7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
216440
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UniGene |
Mm.295246
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RefSeq |
NP_808282
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MGI ID |
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MGI Symbol |
Os9
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OMIM |
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CCDS |
CCDS24229
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HPRD |
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IMGT |
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EMBL |
AC131760
BC031768
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GenPept |
AAH31768
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