InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trf

Summary

InnateDB Protein

IDBP-194239.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trf

Protein Name

transferrin

Synonyms

AI266983; Cd176; HP; hpx; Tf; Tfn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035158

InnateDB Gene

IDBG-194237 (Trf)

Protein Structure

UniProt Annotation

Function

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed by the liver and secreted in plasma. {ECO:0000269PubMed:2601714}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008199	ferric iron binding

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0007015	actin filament organization
GO:0007257	activation of JUN kinase activity
GO:0030316	osteoclast differentiation
GO:0042327	positive regulation of phosphorylation
GO:0045780	positive regulation of bone resorption
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060395	SMAD protein signal transduction
GO:0070371	ERK1 and ERK2 cascade
GO:2000147	positive regulation of cell motility

Cellular Component

GO:0005576	extracellular region
GO:0005768	endosome
GO:0005769	early endosome
GO:0005905	coated pit
GO:0030120	vesicle coat
GO:0030139	endocytic vesicle
GO:0055037	recycling endosome
GO:0097433	dense body