InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crebl2

Summary

InnateDB Protein

IDBP-194264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crebl2

Protein Name

cAMP responsive element binding protein-like 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035304

InnateDB Gene

IDBG-194262 (Crebl2)

Protein Structure

UniProt Annotation

Function

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. {ECO:0000269PubMed:21728997}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21728997}.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in adipose tissue, skeletal muscle, and liver (at protein level). {ECO:0000269PubMed:21728997}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030154	cell differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0045600	positive regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046326	positive regulation of glucose import
GO:0046889	positive regulation of lipid biosynthetic process
GO:0050821	protein stabilization