InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Crebl2

Summary

InnateDB Gene

IDBG-194262.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crebl2

Gene Name

cAMP responsive element binding protein-like 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032652

Encoded Proteins

IDBP-194264

cAMP responsive element binding protein-like 2

IDBP-257069

cAMP responsive element binding protein-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111269:
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41%% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:134830154-134858931

Strand

Forward strand

Band

Transcripts

ENSMUST00000046303	ENSMUSP00000035304
ENSMUST00000111937	ENSMUSP00000107568
ENSMUST00000145643

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030154	cell differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0045600	positive regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046326	positive regulation of glucose import
GO:0046889	positive regulation of lipid biosynthetic process
GO:0050821	protein stabilization

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111269

View Gene Order

ENSBTAG00000011957

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.267010 Mm.397270 Mm.466279 Mm.485635

RefSeq

NM_177687

OMIM

CCDS

CCDS20640

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas