InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smpdl3b

Summary

InnateDB Protein

IDBP-194307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smpdl3b

Protein Name

sphingomyelin phosphodiesterase, acid-like 3B

Synonyms

1110054A24Rik; Asml3b; AU045240;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030709

InnateDB Gene

IDBG-194305 (Smpdl3b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004767	sphingomyelin phosphodiesterase activity
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds

Biological Process

GO:0006685	sphingomyelin catabolic process
GO:0008150	biological_process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1916022

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR017064 Acid sphingomyelinase-like phosphodiesterase, predicted
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PIRSF

PIRSF036767

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P58242